Table 3. Micronucleated binucleated cells (MNBNs) frequency in Caco-2 cells following exposure to fumed or precipitated SiO
2
particles
Treatment
Concentration (µg/mL)
S9 mix
MNBN (%)
Control
0
-
2.0
Positive control (MMS)
25
6.5
Fumed SiO
2
1,000
2.0
Precipitated SiO
2
1,000
2.5
Control
0
+
1.5
Positive control (CPA)
10
7.0
Fumed SiO
2
1,000
1.5
Precipitated SiO
2
1,000
1.0
MMS, methyl methanesulfonate; CPA, cyclophosphamide; -, without; +, with.