Table 4 Blood alcohol, acetaldehyde, and exhaled alcohol concentrations by group after alcohol intake

Variables	Concentration	DA-5521 (n = 22)	Placebo (n = 22)	p-value1)	p-value2)
Blood alcohol (ppm)	AUC	1368.38±254.38	1414.04±276.85	0.2952	0.2947
Blood alcohol (ppm)	Tmax	0.75±0.27	0.65±0.17	0.1073	0.1091
Blood alcohol (ppm)	Cmax	719.63±142.61	736.30±151.10	0.6452	0.6526
Blood acetaldehyde (ppb)	AUC	234.82±297.96	287.78±306.86	0.1037	0.0959
Blood acetaldehyde (ppb)	Tmax	1.56±2.80	1.77±2.36	0.7936	0.7986
Blood acetaldehyde (ppb)	Cmax	74.89±101.40	87.39±104.34	0.2486	0.2435
Breath alcohol (%)	AUC	0.1414±0.0297	0.1494±0.0324	0.2087	0.1571
Breath alcohol (%)	Tmax	0.6705±0.2097	0.6023±0.1258	0.2080	0.1065
Breath alcohol (%)	Cmax	0.0721±0.0138	0.0799±0.0168	0.0117	0.0135

Values are presented as mean±standard deviation.
Analyzed using paired t-test (compared between groups)
Compared within groups: p-value by ANOVA treatment effect
iAUC, incremental area under the curve; C_max, maximum plasma concentration; T_max, time to reach C_max